Protein Modification Reagents
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | C32H44F4N2O13 | 25 MG
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. This product leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC DBCO-PEG4-PFP ester | 95.0% | C36H35F5N2O8 | 25 MG
DBCO-PEG4-PFP ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, incorporating a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs are composed of two ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other the protein of interest. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Used in protac synthesis
- Functions as a click chemistry reagent
- Incorporates a dbco group
- Undergoes strain-promoted alkyne-azide cycloaddition (spaac) with azide groups
- Leverages the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Dde Biotin-PEG4-DBCO | 1807512-43-1 | 96.2% | C47H61N5O9S | 25 MG
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent contains a DBCO group that undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
- Reacts with azide-containing molecules
Medchemexpress LLC DBCO-PEG4-NHS ester | 1427004-19-0 | 99.0% | C34H39N3O10 | 1 G
DBCO-PEG4-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Reacts with azide-containing molecules
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
Medchemexpress LLC DSPE-PEG-Maleimide, MW 5000 | 99.8% | 25 MG
DSPE-PEG-Maleimide, with an average molecular weight of 5000, is a linker lipid composed of DSPE phospholipid and Maleimide. This compound is primarily utilized in the synthesis of various liposome types, including HELDC, sterically stabilized, and immunoliposomes.
- Can be coupled with thiol-p5314-29 peptide
- Used as a linker lipid in immunoliposome synthesis
- Sterically stabilized liposomes containing this compound can be coupled with thiolated monoclonal antibody OX26 (OX26-SH)
- HELDC liposomes prepared with 3% DSPE-PEG-Maleimide show stable particle size over two weeks, with an average diameter of 120 nm
Medchemexpress LLC 3,6,9,15,18,21-Hexaoxa-12-azatricosane-1,23-diol | 63721-14-2 | 98.0% | C16H35NO8 | 50MG
NH-bis-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed with two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for a target protein. They leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Mal-amido-PEG5-C2-NHS ester | 1315355-92-0 | >=98.0% | 557.55 g/mol | C24H35N3O12 | 1 G
Mal-amido-PEG5-C2-NHS ester is a non-cleavable PEG-based linker containing a maleimide and an N-hydroxysuccinimide (NHS) ester for conjugation to thiol and amine groups in proteins, peptides, and oligonucleotides. It is commonly used in antibody-drug conjugate (ADC) synthesis and other bioconjugation research applications.
- Contains maleimide and NHS ester functional groups
- Non-cleavable PEG-based linker for bioconjugation
- CAS number 1315355-92-0
- Molecular weight 557.55 g/mol
- Formula C24H35N3O12
- Appearance viscous liquid, colorless to light yellow
- Purity >=98.0%
- Storage pure form -20°C; in solvent -80°C (6 months) or -20°C (1 month)
- Available in 1 G package
Avanti Polar Lipids DSPE-PEG 2000 AMINE 50MG
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt). 474922-26-4
Medchemexpress LLC Dbco-PEG4-Val-Cit-PAB-MMAF | 2244602-23-9 | 98.7% | 25 MG
DBCO-PEG4-Val-Cit-PAB-MMAF is a drug-linker conjugate used in antibody-drug conjugate research. It combines a cleavable PEG-based Val-Cit-PAB linker bearing a DBCO moiety with the tubulin inhibitor MMAF to enable enzyme-triggered payload release and bioorthogonal conjugation via SPAAC.
- Cleavable Val-Cit-PAB linker for cathepsin-mediated payload release.
- DBCO moiety enables SPAAC click chemistry with azide-functionalized partners.
- Contains MMAF tubulin inhibitor as the cytotoxic payload.
- High purity suitable for research use (approximately 98.7%).
- Available in small research pack sizes such as 25 mg.
Medchemexpress LLC DNP-PEG4-DBCO | 2149585-17-9 | 97.0% | C35H39N5O10 | 25 MG
DNP-PEG4-DBCO is a PEG-based PROTAC linker employed in the synthesis of PROTACs. This click chemistry reagent contains a DBCO group, allowing it to undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- PEG-based PROTAC linker
- Used for PROTACs synthesis
- Click chemistry reagent
- Contains a DBCO group for SPAAC reactions
- Enables targeted protein degradation
Medchemexpress LLC Azide-PEG-amine (MW 5000) | 95.0% | N₃(CH₂CH₂O)nNH₂ | 50 MG
Azide-PEG-amine (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Facilitates protein degradation via PROTACs
- White to off-white solid appearance
- Average molecular weight of 5000
Research Products International Corp PEG 8000, 25 KG
Ultrapure white crystals for molecular biology applications such as precipitation of DNA, nucleic acids, hybridization and fusion of mammalian cells.Melting Point: 55°-60°C
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG6-CH2COOH | 10 g | CAS 437655-96-4 | MDL MFCD26142983
Fmoc-NH-PEG6-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 10 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 437655-96-4
- MDL: MFCD26142983
- InChIKey: HANLHKUCDRJGKX-UHFFFAOYSA-N
- Molecular Weight: 561.628
- Molecular Formula: C29H39NO10
- Purity: ≥95%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22-heptaoxa-4-azatetracosan-24-oic acid
- SMILES: O=C(NCCOCCOCCOCCOCCOCCOCC(O)=O)OCC1C2=C(C3=C1C=CC=C3)C=CC=C2
Medchemexpress LLC Dbco-PEG5-NHS ester | 2144395-59-3 | 693.74 g/mol | C36H43N3O11 | 50 MG
Dbco-PEG5-NHS ester is a heterobifunctional, PEG-based bioorthogonal linker that combines a dibenzocyclooctyne (DBCO) moiety for strain-promoted alkyne-azide cycloaddition with an N-hydroxysuccinimide (NHS) ester for selective coupling to primary amines. It is intended for use in bioconjugation workflows such as antibody-drug conjugate and PROTAC synthesis, and for copper-free click chemistry and surface labeling.
- Enables copper-free click conjugation to azide-containing molecules via the DBCO group.
- Allows rapid amine coupling through the NHS ester at pH 7-9.
- PEG5 spacer improves solubility and reduces steric hindrance.
- Supplied as a small-scale reagent suitable for research and development work.
Medchemexpress LLC Azide-PEG4-VC-PAB-doxorubicin | 99.6% | 1222.25 | C57H75N9O21 | 25 MG
Azide-PEG4-VC-PAB-doxorubicin is an azide-functionalized PEG4 val-cit-PAB linker conjugated to doxorubicin used to prepare antibody-drug conjugates and for click-chemistry applications.
- Contains an azide group for copper-catalyzed and strain-promoted azide-alkyne cycloaddition reactions.
- Includes a protease-cleavable Val-Cit-PAB linker for intracellular payload release.
- Contains doxorubicin as the cytotoxic payload (anthracycline class).
- High listed purity suitable for research (soluble in DMSO at 100 mg/mL).
- Store as a solid at recommended low temperatures for long-term stability.